Cancer is the leading cause of death for the Chinese population, with 4.3 million newly diagnosed cancer patients and 2.8 million deaths in 2013, and the incidence of cancer is still rising rapidly, especially in the case of gastrointestinal cancer. In today’s article, we are going to talk about stevia and cancer.
Most treatments for gastrointestinal cancer involve chemotherapy before or after surgery. Anticancer drugs such as docetaxel, doxorubicin (DOX), 5-fluorouracil (5-FU), and cisplatin (diamine micro platinum (II), CDDP) have non-specificity, drug resistance, and deficiency of toxicity in normal cells. To overcome these limitations, invent new drugs.
Steviol, a rare ingredient in the leaves of Stevia reboudiana bartoni, is also the only colon colonic metabolism of steviol glycosides, a family of natural sweeteners. To date, about 40 steviol glycosides have been discovered on the leaves of Stevia rebaudiana Bertoni. Most of them share a similar metabolic pathway in the human gastrointestinal tract.
Steviol glycosides are not digested until they reach the colon where they are hydrolyzed to sterols. Subsequently, some steviol falling into the enterohepatic circulation is absorbed into the colon and later glucuronidated in the liver; While the rest is available in steviol malls.
Steviol glycosides may not be used as natural sweeteners but may be used to target chemotherapy agents.
Thus, in this study, the intro-anti-proliferation of stevil in human gastrointestinal cancer cells was investigated, and this process was studied with relative protein and MIRNA-related expression analysis.
Steviol prevention on the functioning of gastrointestinal cancer cells
Six human gastrointestinal cell lines were examined by steviol treatment. For comparison, 5-FU was used as a positive control. Figure Figure 11 indicates that steviol inhibits cell function in a time-dependent and dose-dependent manner. Steviol with the same dose (100–200 g / mL) exhibited the same inhibitory efficacy as 5-FU in all acidic cancer cells; At 250 g / mL, steviol provides an even stronger barrier.
Steviol causes phase arrest and apoptosis of gastrointestinal cancer cells
Many anticancer agents inhibit cancer cells through cell phase arrest and cell apoptosis pathways. 1000 ng / ml exposure to 5-FU of SW400 and COLO320DM resulted in G1-S-phase arrest and apoptosis. 5-FE induces apoptosis of gastric cancer cells and up-regulated Bax / BCL-2 ratio in MKN-44 and MKN-45 cell lines.
Specifically, steviol treatment resulted in Caco-2, HCT-116, MKN-45 and HGC-27, G2 seizures, HCT-8 and MGC-803, respectively. Therefore, HCT-116, MKN-45 were selected as representative of gastric and colonic cancer cells, respectively, for subsequent cell apoptosis and subsequent myRNA analysis.
In recent years, a sweet product called stevia (stevioside or steviol) has attracted a lot of public attention. Researchers have found that the main chemical in stevia can be converted into a compound in the laboratory that causes gene mutations. Further studies are needed to find out if the same changes, which can cause cancer, can occur in humans.
The old adage about the cancer wheel on the wheel and the things behind it, those who are really harmed really hold the grain or two of truth. Every time you pour yourself a cup of dinner coffee it seems like you should be given more options for sweeteners – yellow, blue and pink packets are artificially sweet; Caramel colored raw sugar; Good old fashion granular, white stuff; And, recently, sugar substitutes like Stevia and Monkfurt have been billed as “all-natural,” healthier alternatives. So stevia can be the best sweetener for cancer patients.